Interactions of plant food bioactives‐loaded nano delivery systems at the nano‐bio interface and its pharmacokinetics: An overview

Plant food bioactives (PFBs) offer immense health benefits with a greater scope for treating various life-threatening diseases and lifestyle disorders. Knowing their therapeutic potentials, lot of research works are being carried out on formulating PFBs-loaded nano delivery systems (NDSs) to enhance bioefficacy. However, limited information available the interactions occurring at nano-bio interface. Therefore, studies importance towards designing/formulating effective NDSs PFBs. Understanding significance interface bioactive-loaded would help us predict formation biocorona as well correlation between nanoparticles surrounding environments that influenced by NDS's physicochemical properties. The characteristics like size, shape, surface charge will decide fate in biological fluids have been discussed detail. As bioactives-loaded NDS enters gastrointestinal tract, including protein enzyme corona takes place. Subsequently, influences absorption, distribution, metabolism, excretion (ADME) processes thereby its bioavailability, bioefficacy, biosafety. current review focuses understanding journey PBFs-loaded NDSs, nature happening interface, pharmacokinetics In addition, specific case study approach curcumin-loaded reported ADME mechanism comprehensively presented.